Sun Yang
1 media/yang.sun_thumb.jpg 2020-09-18T18:20:35+00:00 Center for UG Excellence 929059fe9a8db94662876b11cdef6e83b70e4c81 34 2 School of Pharmacy plain 2020-09-18T18:24:03+00:00 20170301 105004 20170301 105004 Center for UG Excellence 929059fe9a8db94662876b11cdef6e83b70e4c81This page is referenced by:
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Dr. Sun Yang
15
Pharmacy
plain
2020-10-16T20:03:02+00:00
Email: syang@chapman.edu
College: School of Pharmacy
Overview of scholarly research/creative activity: The aberrant pathways in cancer cells may be utilized for developing targeted therapeutics. My translational research focuses on identifying promising druggable targets and developing potent inhibitors for melanoma therapy. I am also interested in studying medication safety and clinical outcomes of medication treatment in children.
Specific projects working on: APE/Ref-1 is a multifunctional protein that plays an important role in both DNA damage repair and cellular responses to redox signaling. My studies demonstrated that melanoma cells exhibit significantly higher levels of APE/Ref-1 compared to normal melanocytes, which stimulated proliferation and metastasis and contributed to chemotherapeutic drug resistance. Using a structure-aided drug design approach, we aim to develop potent APE/Ref-1 inhibitors that preferentially bind to and stabilize the inactive conformation of the protein as potential anti-cancer therapeutic agents. Our leading compounds have already exhibited promising anti-melanoma activities.
Number of students looking to work with: 1-2
Time commitment for students: 6-8 hours per week.
When students are needed: Interterm 2021, Spring 2021, Summer 2021
What would students be expected to do: Lab experiments, weekly group meeting, analyzing and presenting experiment results.
